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Inhibition of HDAC3 promotes ligand-independent PPARγ activation by protein acetylation
PPARγ (peroxisome proliferator-activated receptor gamma) is a nuclear receptor whose activation is dependent on a ligand. PPARγ activation by exogenous ligands, such as thiazolidinediones (TZDs), is a strategy in the treatment of type 2 diabetes for the improvement of insulin sensitivity. In additio...
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| Publicado no: | J Mol Endocrinol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4391273/ https://ncbi.nlm.nih.gov/pubmed/24982244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-14-0066 |
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