Use of Mechanistic Models to Integrate and Analyze Multiple Proteomic Datasets

Proteins in cell signaling networks tend to interact promiscuously through low-affinity interactions. Consequently, evaluating the physiological importance of mapped interactions can be difficult. Attempts to do so have tended to focus on single, measurable physicochemical factors, such as affinity...

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Bibliografiset tiedot
Julkaisussa:Biophys J
Päätekijät: Stites, Edward C., Aziz, Meraj, Creamer, Matthew S., Von Hoff, Daniel D., Posner, Richard G., Hlavacek, William S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Biophysical Society 2015
Aiheet:
Systems Biophysics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390817/
https://ncbi.nlm.nih.gov/pubmed/25863072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.02.030
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