DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

MLL -rearrangements generate MLL-fusion proteins that bind DNA and drive leukemogenic gene expression. This gene expression program is dependent on the histone 3 lysine 79 (H3K79) methyltransferase DOT1L, and small molecule DOT1L inhibitors show promise as therapeutics for these leukemias. However,...

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Udgivet i:Nat Med
Main Authors: Chen, C.W., Koche, R.P., Sinha, A.U., Deshpande, A.J., Zhu, N., Eng, R., Doench, J.G., Xu, H., Chu, S.H., Qi, J., Wang, X., Delaney, C., Bernt, K.M., Root, D.E., Hahn, W.C., Bradner, J.E., Armstrong, S.A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390532/
https://ncbi.nlm.nih.gov/pubmed/25822366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3832
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