Identification of autoreactive CD4(+) and CD8(+) T cell subsets resistant to PD-1 pathway blockade

Programmed Death (PD)-1 promotes T cell tolerance. Despite therapeutically targeting this pathway for chronic infections and tumors, little is known about how different T cell subsets are affected during blockade. We examined PD-1/PD-L1 regulation of self-antigen-specific CD4 and CD8 T cells in auto...

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Pubblicato in:J Immunol
Autori principali: Pauken, Kristen E, Nelson, Christine E, Martinov, Tijana, Spanier, Justin A, Heffernan, James R, Sahli, Nathanael L, Quarnstrom, Clare F, Osum, Kevin C, Schenkel, Jason M, Jenkins, Marc K, Blazar, Bruce R, Vezys, Vaiva, Fife, Brian T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390507/
https://ncbi.nlm.nih.gov/pubmed/25769925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402262
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