A highly conserved program of neuronal microexons is misregulated in autistic brains

Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However, which of the myriad of detected AS events provide important biological functions is not well understood. Here, we define the largest program of functionally coordinated, neural-regulated AS described to date i...

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Vydáno v:Cell
Hlavní autoři: Irimia, Manuel, Weatheritt, Robert J., Ellis, Jonathan, Parikshak, Neelroop N., Gonatopoulos-Pournatzis, Thomas, Babor, Mariana, Quesnel-Vallières, Mathieu, Tapial, Javier, Raj, Bushra, O’Hanlon, Dave, Barrios-Rodiles, Miriam, Sternberg, Michael J.E., Cordes, Sabine P., Roth, Frederick P., Wrana, Jeffrey L., Geschwind, Daniel H., Blencowe, Benjamin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390143/
https://ncbi.nlm.nih.gov/pubmed/25525873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.035
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