HER-2 gene amplification can be acquired as breast cancer progresses

Amplification and overexpression of the HER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between primary tumor and metastases. Therefore, patients with HER-2-negative primary tumors rarely will receive anti-Her-2 antibody (trastuzumab, Herceptin) therapy...

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Autori principali: Meng, Songdong, Tripathy, Debasish, Shete, Sanjay, Ashfaq, Raheela, Haley, Barbara, Perkins, Steve, Beitsch, Peter, Khan, Amanullah, Euhus, David, Osborne, Cynthia, Frenkel, Eugene, Hoover, Susan, Leitch, Marilyn, Clifford, Edward, Vitetta, Ellen, Morrison, Larry, Herlyn, Dorothee, Terstappen, Leon W. M. M., Fleming, Timothy, Fehm, Tanja, Tucker, Thomas, Lane, Nancy, Wang, Jianqiang, Uhr, Jonathan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC438987/
https://ncbi.nlm.nih.gov/pubmed/15194824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402993101
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