Synergy Between Surface and Core Entrapped Metals in a Mixed Manganese-Gadolinium Nanocolloid Affords Safer MR Imaging of Sparse Biomarkers

High-relaxivity T1-weighted (T1w) MR molecular imaging nanoparticles typically present high surface gadolinium payloads that can elicit significant acute complement activation (CA). The objective of this research was to develop a high T1 contrast nanoparticle, which reduced gadolinium exposure, mini...

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Pubblicato in:Nanomedicine
Autori principali: Wang, Kezheng, Pan, Dipanjan, Schmieder, Anne H., Senpan, Angana, Hourcade, Dennis E., Pham, Christine TN, Mitchel, Lynne M., Caruthers, Shelton D., Cui, Grace, Wickline, Samuel A., Shen, Baozhong, Lanza, Gregory M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389679/
https://ncbi.nlm.nih.gov/pubmed/25652900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2014.12.009
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