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Protein tolerance to random amino acid change
Mutagenesis of protein-encoding sequences occurs ubiquitously; it enables evolution, accumulates during aging, and is associated with disease. Many biotechnological methods exploit random mutations to evolve novel proteins. To quantitate protein tolerance to random change, it is vital to understand...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC438954/ https://ncbi.nlm.nih.gov/pubmed/15197260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403255101 |
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