α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2

Accumulating evidence from genetic and biochemical studies implicates dysfunction of the autophagic-lysosomal pathway as a key feature in the pathogenesis of Parkinson's disease (PD). Most studies have focused on accumulation of neurotoxic α-synuclein secondary to defects in autophagy as the ca...

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Publicado no:J Neurosci
Main Authors: Kett, Lauren R., Stiller, Barbara, Bernath, Megan M., Tasset, Inmaculada, Blesa, Javier, Jackson-Lewis, Vernice, Chan, Robin B., Zhou, Bowen, Di Paolo, Gilbert, Przedborski, Serge, Cuervo, Ana Maria, Dauer, William T.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388928/
https://ncbi.nlm.nih.gov/pubmed/25855184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0632-14.2015
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