Baclofen, a GABA(B)R Agonist, Ameliorates Immune-Complex Mediated Acute Lung Injury by Modulating Pro-Inflammatory Mediators

Immune-complexes play an important role in the inflammatory diseases of the lung. Neutrophil activation mediates immune-complex (IC) deposition-induced acute lung injury (ALI). Components of gamma amino butyric acid (GABA) signaling, including GABA B receptor 2 (GABA(B)R2), GAD65/67 and the GABA tra...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Jin, Shunying, Merchant, Michael L., Ritzenthaler, Jeffrey D., McLeish, Kenneth R., Lederer, Eleanor D., Torres-Gonzalez, Edilson, Fraig, Mostafa, Barati, Michelle T., Lentsch, Alex B., Roman, Jesse, Klein, Jon B., Rane, Madhavi J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388838/
https://ncbi.nlm.nih.gov/pubmed/25848767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121637
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