Nucleosides Present on Phlebotomine Saliva Induce Immunossuppression and Promote the Infection Establishment

BACKGROUND: Sand fly saliva plays a crucial role in establishing Leishmania infection. We identified adenosine (ADO) and adenosine monophosphate (AMP) as active pharmacologic compounds present in Phlebotomus papatasi saliva that inhibit dendritic cell (DC) functions through a PGE(2)/IL 10-dependent...

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Udgivet i:PLoS Negl Trop Dis
Main Authors: Carregaro, Vanessa, Ribeiro, José M., Valenzuela, Jesus G., Souza-Júnior, Djalma L., Costa, Diego L., Oliveira, Carlo J. F., Sacramento, Laís A., Nascimento, Manuela S. L., Milanezi, Cristiane M., Cunha, Fernando Q., Silva, João S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388340/
https://ncbi.nlm.nih.gov/pubmed/25849562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003600
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