Differential Effects of IL-17A and TNF-α on Osteoblastic Differentiation of Isolated Synoviocytes and on Bone Explants from Arthritis Patients

OBJECTIVE: TNF-α and IL-17A act on fibroblast-like synoviocytes (FLS) and contribute to cytokine production, inflammation, and tissue destruction in rheumatoid arthritis (RA). The aim of this study was to compare their effects on osteogenic differentiation of isolated FLS and on whole bone explants...

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Publicado en:Front Immunol
Main Authors: Osta, Bilal, Roux, Jean-Paul, Lavocat, Fabien, Pierre, Marlène, Ndongo-Thiam, Ndieme, Boivin, Georges, Miossec, Pierre
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2015
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387961/
https://ncbi.nlm.nih.gov/pubmed/25904914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00151
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