Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches

Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway. Although the requirement for Hedgehog in BCC is well-established, the identity of disease-initiating cells and the compartments in which they reside remain controversial...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Peterson, Shelby C., Eberl, Markus, Vagnozzi, Alicia N., Belkadi, Abdelmadjid, Veniaminova, Natalia A., Verhaegen, Monique E., Bichakjian, Christopher K., Ward, Nicole L., Dlugosz, Andrzej A., Wong, Sunny Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387376/
https://ncbi.nlm.nih.gov/pubmed/25842978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.02.006
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