A single glycan on IgE is indispensable for initiation of anaphylaxis

Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which affect more than 1 in 10 individuals worldwide. IgE specific for innocuous environmental antigens, or allergens, binds and sensitizes tissue-resident mast cells expressing the high-affinity IgE receptor, FcεRI. S...

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Udgivet i:J Exp Med
Main Authors: Shade, Kai-Ting C., Platzer, Barbara, Washburn, Nathaniel, Mani, Vinidhra, Bartsch, Yannic C., Conroy, Michelle, Pagan, Jose D., Bosques, Carlos, Mempel, Thorsten R., Fiebiger, Edda, Anthony, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387292/
https://ncbi.nlm.nih.gov/pubmed/25824821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142182
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