Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer

We utilized three tiers of screening to identify novel therapeutic agents for pancreatic cancers. First, we analyzed 14 pancreatic cancer cell lines against a panel of 66 small‐molecule kinase inhibitors and dasatinib was the most potent. Second, we performed RNA expression analysis on 3 dasatinib‐r...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Chien, Wenwen, Sun, Qiao-Yang, Lee, Kian Leong, Ding, Ling-Wen, Wuensche, Peer, Torres-Fernandez, Lucia A., Tan, Siew Zhuan, Tokatly, Itay, Zaiden, Norazean, Poellinger, Lorenz, Mori, Seiichi, Yang, Henry, Tyner, Jeffrey W., Koeffler, H. Phillip
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387089/
https://ncbi.nlm.nih.gov/pubmed/25637283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.01.002
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