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The role of hexokinase in cardioprotection – mechanism and potential for translation

Mitochondrial permeability transition pore (mPTP) opening plays a critical role in cardiac reperfusion injury and its prevention is cardioprotective. Tumour cell mitochondria usually have high levels of hexokinase isoform 2 (HK2) bound to their outer mitochondrial membranes (OMM) and HK2 binding to...

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Publicat a:Br J Pharmacol
Autors principals: Halestrap, Andrew P, Pereira, Gonçalo C, Pasdois, Philippe
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386983/
https://ncbi.nlm.nih.gov/pubmed/25204670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12899
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