Bexarotene Reduces Blood-Brain Barrier Permeability in Cerebral Ischemia-Reperfusion Injured Rats

BACKGROUND: Matrix metalloproteinase-9 (MMP-9) over-expression disrupts the blood-brain barrier (BBB) in the ischemic brain. The retinoid X receptor agonist bexarotene suppresses MMP-9 expression in endothelial cells and displays neuroprotective effects. Therefore, we hypothesized that bexarotene ma...

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Udgivet i:PLoS One
Main Authors: Xu, Lu, Cao, Fang, Xu, Feng, He, Baicheng, Dong, Zhi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386818/
https://ncbi.nlm.nih.gov/pubmed/25844636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122744
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