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Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112
INTRODUCTION: SNX-2112 is a promising anticancer agent but has poor solubility in both water and oil. In the study reported here, we aimed to develop a nanocrystal formulation for SNX-2112 and to determine the pharmacokinetic behaviors of the prepared nanocrystals. METHODS: Nanocrystals of SNX-2112...
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| Publicado no: | Int J Nanomedicine |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4386773/ https://ncbi.nlm.nih.gov/pubmed/25848269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S79734 |
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