Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

Current mechanisms of arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia (CPVT) require spontaneous Ca(2+) release via cardiac ryanodine receptor (RyR2) channels affected by gain-of-function mutations. Hence, hyperactive RyR2 channels eager to release Ca(2+) on their own appea...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhao, Yan-Ting, Valdivia, Carmen R., Gurrola, Georgina B., Powers, Patricia P., Willis, B. Cicero, Moss, Richard L., Jalife, José, Valdivia, Héctor H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386375/
https://ncbi.nlm.nih.gov/pubmed/25775566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419795112
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