Heterogeneity of Ryanodine Receptor Dysfunction in a Mouse Model Of Catecholaminergic Polymorphic Ventricular Tachycardia

RATIONALE: Most cardiac ryanodine receptor (RyR2) mutations associated with Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) are postulated to cause one distinctive form of Ca(2+) release dysfunction. Considering the spread distribution of CPVT mutations, we hypothesized that dysfunction...

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Detalhes bibliográficos
Main Authors: Loaiza, Randall, Benkusky, Nancy A., Powers, Patricia P., Hacker, Timothy, Noujaim, Sami, Ackerman, Michael J., Jalife, José, Valdivia, Héctor H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549355/
https://ncbi.nlm.nih.gov/pubmed/23152493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.274803
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