CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction

Hypoxic pulmonary vasoconstriction (HPV) optimizes pulmonary ventilation-perfusion matching in regional hypoxia, but promotes pulmonary hypertension in global hypoxia. Ventilation-perfusion mismatch is a major cause of hypoxemia in cystic fibrosis. We hypothesized that cystic fibrosis transmembrane...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tabeling, Christoph, Yu, Hanpo, Wang, Liming, Ranke, Hannes, Goldenberg, Neil M., Zabini, Diana, Noe, Elena, Krauszman, Adrienn, Gutbier, Birgitt, Yin, Jun, Schaefer, Michael, Arenz, Christoph, Hocke, Andreas C., Suttorp, Norbert, Proia, Richard L., Witzenrath, Martin, Kuebler, Wolfgang M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386337/
https://ncbi.nlm.nih.gov/pubmed/25829545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421190112
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