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PROLONGING THE SURVIVAL OF Tsc2 CONDITIONAL KNOCKOUT MICE BY GLUTAMINE SUPPLEMENTATION
The genetic disease tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by loss of function mutations in either TSC1 (hamartin) or TSC2 (tuberin), which serve as negative regulators of mechanistic target of rapamycin complex 1 (mTORC1) activity. TSC patients exhibit development...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4386275/ https://ncbi.nlm.nih.gov/pubmed/25613864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.01.039 |
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