Mutation of Vav1 adaptor region reveals a new oncogenic activation

Vav family members function as remarkable scaffold proteins that exhibit both GDP/GTP exchange activity for Rho/Rac GTPases and numerous protein-protein interactions via three adaptor Src-homology domains. The exchange activity is under the unique regulation by phosphorylation of tyrosine residues h...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Razanadrakoto, Lyra, Cormier, Françoise, Laurienté, Vanessa, Dondi, Elisabetta, Gardano, Laura, Katzav, Shulamit, Guittat, Lionel, Varin-Blank, Nadine
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385868/
https://ncbi.nlm.nih.gov/pubmed/25426554
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