Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers

Acquired resistance to PI3K/mTOR/Akt pathway inhibitors is often associated with compensatory feedback loops involving the activation of oncogenes. Here, we have generated everolimus resistance in ER+ breast cancer cells and in long-term estrogen deprived (LTED) models that mimic progression on anti...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Bihani, Teeru, Ezell, Scott A., Ladd, Brendon, Grosskurth, Shaun E., Mazzola, Anne Marie, Pietras, Mark, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2014
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385860/
https://ncbi.nlm.nih.gov/pubmed/25537515
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