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Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei
Cyclic nucleotide phosphodiesterases (PDEs) have been identified as important enzyme targets for drug development in both humans and in Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). With this in mind, we recently reported the profiling of a range of human PDE inhibi...
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| Publicat a: | Chem Biol Drug Des |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4385514/ https://ncbi.nlm.nih.gov/pubmed/25283372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12443 |
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