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DJ1 represses glycolysis and cell proliferation by transcriptionally upregulating pink1

DJ1 is a multifunctional protein whose mutations cause autosomal recessive early-onset Parkinson disease (PD). DJ1 loss of function disrupts mitochondrial function, but the signaling pathway whereby it interferes with energy metabolism is unknown. Here, we found that mouse embryonic fibroblasts obta...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Requejo-Aguilar, Raquel, Lopez-Fabuel, Irene, Jimenez-Blasco, Daniel, Fernandez, Emilio, Almeida, Angeles, Bolaños, Juan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385472/
https://ncbi.nlm.nih.gov/pubmed/25670069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20141025
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