Synthesis and structure-activity relationships of a series 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter

The synthesis and SAR of 4-methoxy-3-(piperidin-4-yl) benzamides identified after a high-throughput screen of the MLPCN library is reported. SAR was explored around the 3-piperidine subtituent as well as the amide functionality of the reported compounds. Starting from the initial lead compounds, 1-7...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: Bollinger, Sean R., Engers, Darren W., Ennis, Elizabeth A., Wright, Jane, Locuson, Charles W., Lindsley, Craig W., Blakely, Randy D., Hopkins, Corey R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385452/
https://ncbi.nlm.nih.gov/pubmed/25801932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.02.058
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller