The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule

BACKGROUND: Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An accurate method for monitoring these processes might be the use of radiolabell...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: van Uhm, Janneke IM, Visser, Gerard WM, van der Schans, Marcel J, Geldof, Albert A, Meuleman, Eric JH, Nieuwenhuijzen, Jakko A
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385017/
https://ncbi.nlm.nih.gov/pubmed/25853011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-015-0083-5
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