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Fine-tuning Interaction between Aminoacyl-tRNA Synthetase and tRNA for Efficient Synthesis of Proteins Containing Unnatural Amino Acids
[Image: see text] By using a directed evolution approach, we have identified aminoacyl-tRNA synthetase variants with significantly enhanced activity for the incorporation of unnatural amino acids into proteins in response to the amber nonsense codon in bacteria. We demonstrated that the optimization...
में बचाया:
| में प्रकाशित: | ACS Synth Biol |
|---|---|
| मुख्य लेखकों: | , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Chemical
Society
2014
|
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384836/ https://ncbi.nlm.nih.gov/pubmed/24847685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/sb500195w |
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