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Fine-tuning Interaction between Aminoacyl-tRNA Synthetase and tRNA for Efficient Synthesis of Proteins Containing Unnatural Amino Acids
[Image: see text] By using a directed evolution approach, we have identified aminoacyl-tRNA synthetase variants with significantly enhanced activity for the incorporation of unnatural amino acids into proteins in response to the amber nonsense codon in bacteria. We demonstrated that the optimization...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Synth Biol |
|---|---|
| Κύριοι συγγραφείς: | , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical
Society
2014
|
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384836/ https://ncbi.nlm.nih.gov/pubmed/24847685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/sb500195w |
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