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Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes
An outstanding question is how receptor tyrosine kinases (RTKs) determine different cell-fate decisions despite sharing the same signalling cascades. Here, we uncovered an unexpected mechanism of RTK trafficking in this process. By quantitative high-resolution FRET microscopy, we found that phosphor...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384751/ https://ncbi.nlm.nih.gov/pubmed/25650738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06156 |
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