APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

Endocytosis allows cargo to enter a series of specialized endosomal compartments, beginning with early endosomes harboring Rab5 and its effector EEA1. There are, however, additional structures labeled by the Rab5 effector APPL1 whose role in endocytic transport remains unclear. It has been proposed...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Cell Biol
Main Authors: Kalaidzidis, Inna, Miaczynska, Marta, Brewińska-Olchowik, Marta, Hupalowska, Anna, Ferguson, Charles, Parton, Robert G., Kalaidzidis, Yannis, Zerial, Marino
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2015
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602042/
https://ncbi.nlm.nih.gov/pubmed/26459602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201311117
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