APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

Endocytosis allows cargo to enter a series of specialized endosomal compartments, beginning with early endosomes harboring Rab5 and its effector EEA1. There are, however, additional structures labeled by the Rab5 effector APPL1 whose role in endocytic transport remains unclear. It has been proposed...

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Detalles Bibliográficos
Publicado en:J Cell Biol
Main Authors: Kalaidzidis, Inna, Miaczynska, Marta, Brewińska-Olchowik, Marta, Hupalowska, Anna, Ferguson, Charles, Parton, Robert G., Kalaidzidis, Yannis, Zerial, Marino
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602042/
https://ncbi.nlm.nih.gov/pubmed/26459602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201311117
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