Effect of airway acidosis and alkalosis on airway vascular smooth muscle responsiveness to albuterol

BACKGROUND: In vitro and animal experiments have shown that the transport and signaling of β(2)-adrenergic agonists are pH-sensitive. Inhaled albuterol, a hydrophilic β(2)-adrenergic agonist, is widely used for the treatment of obstructive airway diseases. Acute exacerbations of obstructive airway d...

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Bibliografiske detaljer
Udgivet i:BMC Pharmacol Toxicol
Main Authors: Cancado, Jose E, Mendes, Eliana S, Arana, Johana, Horvath, Gabor, Monzon, Maria E, Salathe, Matthias, Wanner, Adam
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384333/
https://ncbi.nlm.nih.gov/pubmed/25889594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-015-0008-y
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