Evidence against the ‘Y-T coupling’ mechanism of activation in the response regulator NtrC

The dominant theory on the mechanism of response regulators activation in two-component bacterial signaling systems is the ‘Y-T coupling’ mechanism, wherein the χ(1) rotameric state of a highly conserved aromatic residue correlates with the activation of the protein via structural rearrangements cou...

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Bibliographic Details
Published in:J Mol Biol
Main Authors: Villali, Janice, Pontiggia, Francesco, Clarkson, Michael W., Hagan, Michael F., Kern, Dorothee
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384162/
https://ncbi.nlm.nih.gov/pubmed/24406745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.12.027
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