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Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts

The aims of this study were to investigate the impact of caloric restriction (CR) on cardiac telomere biology in an animal model of diabetes and to examine the signal transduction involved in cell senescence as well as cardiac function. Male 8-week-old Otsuka Long-Evans Tokushima fatty (OLETF) diabe...

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Detalhes bibliográficos
Publicado no:Mol Cell Biochem
Main Authors: Makino, Naoki, Oyama, Jun-ichi, Maeda, Toyoki, Koyanagi, Masamichi, Higuchi, Yoshihiro, Tsuchida, Keiko
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383823/
https://ncbi.nlm.nih.gov/pubmed/25662949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-015-2327-0
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