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Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts

The aims of this study were to investigate the impact of caloric restriction (CR) on cardiac telomere biology in an animal model of diabetes and to examine the signal transduction involved in cell senescence as well as cardiac function. Male 8-week-old Otsuka Long-Evans Tokushima fatty (OLETF) diabe...

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Vydáno v:Mol Cell Biochem
Hlavní autoři: Makino, Naoki, Oyama, Jun-ichi, Maeda, Toyoki, Koyanagi, Masamichi, Higuchi, Yoshihiro, Tsuchida, Keiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383823/
https://ncbi.nlm.nih.gov/pubmed/25662949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-015-2327-0
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