Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies

We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet ge...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Di Buduo, Christian A., Wray, Lindsay S., Tozzi, Lorenzo, Malara, Alessandro, Chen, Ying, Ghezzi, Chiara E., Smoot, Daniel, Sfara, Carla, Antonelli, Antonella, Spedden, Elise, Bruni, Giovanna, Staii, Cristian, De Marco, Luigi, Magnani, Mauro, Kaplan, David L., Balduini, Alessandra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2015
Onderwerpen:
Platelets and Thrombopoiesis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383799/
https://ncbi.nlm.nih.gov/pubmed/25575540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-595561
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