Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies

We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet ge...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Di Buduo, Christian A., Wray, Lindsay S., Tozzi, Lorenzo, Malara, Alessandro, Chen, Ying, Ghezzi, Chiara E., Smoot, Daniel, Sfara, Carla, Antonelli, Antonella, Spedden, Elise, Bruni, Giovanna, Staii, Cristian, De Marco, Luigi, Magnani, Mauro, Kaplan, David L., Balduini, Alessandra
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2015
Pynciau:
Platelets and Thrombopoiesis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383799/
https://ncbi.nlm.nih.gov/pubmed/25575540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-595561
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg