Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies

We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet ge...

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Bibliographic Details
Published in:Blood
Main Authors: Di Buduo, Christian A., Wray, Lindsay S., Tozzi, Lorenzo, Malara, Alessandro, Chen, Ying, Ghezzi, Chiara E., Smoot, Daniel, Sfara, Carla, Antonelli, Antonella, Spedden, Elise, Bruni, Giovanna, Staii, Cristian, De Marco, Luigi, Magnani, Mauro, Kaplan, David L., Balduini, Alessandra
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Platelets and Thrombopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383799/
https://ncbi.nlm.nih.gov/pubmed/25575540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-595561
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