Targeting of Runx2 by miRNA-135 and miRNA-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease

Progression of breast cancer to metastatic bone disease is linked to deregulated expression of the transcription factor Runx2. Therefore, our goal was to evaluate the potential for clinical use of Runx2-targeting microRNAs (miRNAs) to reduce tumor growth and bone metastatic burden. Expression analys...

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Publicado en:Cancer Res
Autores principales: Taipaleenmäki, Hanna, Browne, Gillian, Akech, Jacqueline, Zustin, Jozef, van Wijnen, Andre J., Stein, Janet L., Hesse, Eric, Stein, Gary S., Lian, Jane B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383679/
https://ncbi.nlm.nih.gov/pubmed/25634212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1026
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