Melatonin Prevents Myeloperoxidase Heme Destruction and the Generation of Free Iron Mediated by Self-Generated Hypochlorous Acid

Myeloperoxidase (MPO) generated hypochlorous acid (HOCl) formed during catalysis is able to destroy the MPO heme moiety through a feedback mechanism, resulting in the accumulation of free iron. Here we show that the presence of melatonin (MLT) can prevent HOCl-mediated MPO heme destruction using a c...

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Udgivet i:PLoS One
Main Authors: Shaeib, Faten, Khan, Sana N., Ali, Iyad, Najafi, Tohid, Maitra, Dhiman, Abdulhamid, Ibrahim, Saed, Ghassan M., Pennathur, Subramaniam, Abu-Soud, Husam M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383586/
https://ncbi.nlm.nih.gov/pubmed/25835505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120737
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