Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein

Homozygous mutations in the glucocerebrosidase (GBA) gene result in Gaucher disease (GD), the most common lysosomal storage disease. Recent genetic studies have revealed that GBA mutations confer a strong risk for sporadic Parkinson’s disease (PD). To investigate how GBA mutations cause PD, we gener...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Uemura, Norihito, Koike, Masato, Ansai, Satoshi, Kinoshita, Masato, Ishikawa-Fujiwara, Tomoko, Matsui, Hideaki, Naruse, Kiyoshi, Sakamoto, Naoaki, Uchiyama, Yasuo, Todo, Takeshi, Takeda, Shunichi, Yamakado, Hodaka, Takahashi, Ryosuke
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383526/
https://ncbi.nlm.nih.gov/pubmed/25835295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005065
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