Selective Activity of the Histone Deacetylase Inhibitor AR-42 against Leukemia Stem Cells: A Novel Potential Strategy in Acute Myelogenous Leukemia

Most patients with acute myelogenous leukemia (AML) relapse and die of their disease. Increasing evidence indicates that AML relapse is driven by the inability to eradicate leukemia stem cells (LSC). Thus, it is imperative to identify novel therapies that can ablate LSCs. Using an in silico gene exp...

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Udgivet i:Mol Cancer Ther
Main Authors: Guzman, Monica L., Yang, Neng, Sharma, Krishan K., Balys, Marlene, Corbett, Cheryl A., Jordan, Craig T., Becker, Michael W., Steidl, Ulrich, Abdel-Wahab, Omar, Levine, Ross L., Marcucci, Guido, Roboz, Gail J., Hassane, Duane C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383047/
https://ncbi.nlm.nih.gov/pubmed/24934933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0963
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