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Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design

Organometallic complexes are effective hydrogenation catalysts for organic reactions. For example, Noyori-type ruthenium complexes catalyse reduction of ketones by transfer of hydride from formate. Here we show that such catalytic reactions can be achieved in cancer cells, offering a new strategy fo...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha, Sadler, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383003/
https://ncbi.nlm.nih.gov/pubmed/25791197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7582
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