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Release, Partitioning, and Conjugation Stability of Doxorubicin in Polymer Micelles Determined by Mechanistic Modeling
PURPOSE: To better understand the mechanistic parameters that govern drug release from polymer micelles with acid-labile linkers. METHODS: A mathematical model was developed to describe drug release from block copolymer micelles composed of a poly(ethylene glycol) shell and a poly(aspartate) core, m...
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| Veröffentlicht in: | Pharm Res |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382418/ https://ncbi.nlm.nih.gov/pubmed/25407546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1573-2 |
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