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Release, Partitioning, and Conjugation Stability of Doxorubicin in Polymer Micelles Determined by Mechanistic Modeling

PURPOSE: To better understand the mechanistic parameters that govern drug release from polymer micelles with acid-labile linkers. METHODS: A mathematical model was developed to describe drug release from block copolymer micelles composed of a poly(ethylene glycol) shell and a poly(aspartate) core, m...

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Bibliografske podrobnosti
izdano v:Pharm Res
Main Authors: Ponta, Andrei, Fugit, Kyle D., Anderson, Bradley D., Bae, Younsoo
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382418/
https://ncbi.nlm.nih.gov/pubmed/25407546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1573-2
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