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Kinesin’s Front Head is Gated by the Backward Orientation of its Neck Linker
Kinesin-1 is a two-headed motor that takes processive 8-nm hand-over-hand steps and transports intracellular cargos towards the plus end of microtubules. Processive motility requires a gating mechanism to coordinate the mechanochemical cycles of the two heads. Kinesin gating involves the neck linker...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382375/ https://ncbi.nlm.nih.gov/pubmed/25818289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.061 |
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