Cyclin-Dependent Kinase Five Mediates Activation of Lung Xanthine Oxidoreductase in Response to Hypoxia

BACKGROUND: Xanthine oxidoreductase (XOR) is involved in oxidative metabolism of purines and is a source of reactive oxygen species (ROS). As such, XOR has been implicated in oxidant-mediated injury in multiple cardiopulmonary diseases. XOR enzyme activity is regulated, in part, via a phosphorylatio...

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Pubblicato in:PLoS One
Autori principali: Kim, Bo S., Serebreni, Leonid, Fallica, Jonathan, Hamdan, Omar, Wang, Lan, Johnston, Laura, Kolb, Todd, Damarla, Mahendra, Damico, Rachel, Hassoun, Paul M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382197/
https://ncbi.nlm.nih.gov/pubmed/25831123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124189
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