Systematic Mutagenesis of Genes Encoding Predicted Autotransported Proteins of Burkholderia pseudomallei Identifies Factors Mediating Virulence in Mice, Net Intracellular Replication and a Novel Protein Conferring Serum Resistance

Burkholderia pseudomallei is the causative agent of the severe tropical disease melioidosis, which commonly presents as sepsis. The B. pseudomallei K96243 genome encodes eleven predicted autotransporters, a diverse family of secreted and outer membrane proteins often associated with virulence. In a...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Adler, Natalie R. Lazar, Stevens, Mark P., Dean, Rachel E., Saint, Richard J., Pankhania, Depesh, Prior, Joann L., Atkins, Timothy P., Kessler, Bianca, Nithichanon, Arnone, Lertmemongkolchai, Ganjana, Galyov, Edouard E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382181/
https://ncbi.nlm.nih.gov/pubmed/25830295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121271
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