Systematic Mutagenesis of Genes Encoding Predicted Autotransported Proteins of Burkholderia pseudomallei Identifies Factors Mediating Virulence in Mice, Net Intracellular Replication and a Novel Protein Conferring Serum Resistance

Burkholderia pseudomallei is the causative agent of the severe tropical disease melioidosis, which commonly presents as sepsis. The B. pseudomallei K96243 genome encodes eleven predicted autotransporters, a diverse family of secreted and outer membrane proteins often associated with virulence. In a...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Adler, Natalie R. Lazar, Stevens, Mark P., Dean, Rachel E., Saint, Richard J., Pankhania, Depesh, Prior, Joann L., Atkins, Timothy P., Kessler, Bianca, Nithichanon, Arnone, Lertmemongkolchai, Ganjana, Galyov, Edouard E.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382181/
https://ncbi.nlm.nih.gov/pubmed/25830295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121271
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